Biaxin (Clarithromycin)

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Each Klaricid XL tablet contains 500 mg of the active ingredient clarithromycin. Klaricid belongs to a group of medicines called macrolide antibiotics. Antibiotics stop the growth of bacteria (bugs) which cause infections.

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See also Macrolide antibiotics Clarithromycin is a commonly used macrolide antibiotic and is a regular part of regimens for the eradication of Helicobacter pylori, often in combination with a nitromidazole antibiotic as well, in addition to a proton pump inhibitor. Variable rates of adverse events (4-30%) have been reported with clarithromycin.

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In three patients with pulmonary MAC and aspergillosis infections, itraconazole was suggested to increase the plasma concentration of clarithromycin as well as the clarithromycin:14-hydroxyclarithromycin ratio. This effect may have been due to inhibition of CYP3A4 by itraconazole. Cisapride can prolong the QT interval, with a risk of ventricular dysrhythmias. Clarithromycin increases serum concentrations of cisapride.

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Intravenous clarithromycin caused thrombophlebitis in four patients when it was given inappropriately as a rapid bolus injection instead of a short infusion; the manufacturers have received other reports of similar reactions, even with infusions, but the incidence seems to be considerably lower than with erythromycin. In a prospective, non-randomized study, phlebitis occurred in 15 of 19 patients treated with intravenous erythromycin (incidence rate of 0.40 episodes/patient-day) and in 19 of 25 patients treated with intravenous clarithromycin (0.35 episodes/patient-day).