Levaquin (Levofloxacin)

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In patients with meningitis, levofloxacin penetration in cerebrospinal fluid and the liquor-to-plasma ratio was assessed at 2 hours after dosing in five patients with spontaneous acute bacterial meningitis. Cerebrospinal fluid levofloxacin concentration at 2 hours after dosing was 2.0 µg/ml, and the liquor-to-plasma ratio at 2 hours after dosing was 0.35. In 10 patients who took levofloxacin 500 mg/day and rifampicin 600 mg/day for 2-6 months, there were no adverse reactions in 46% of patients, occasional digestive symptoms in 40%, and mild diarrhea in 13%; these patients also took unspecified anti-inflammatory drugs.

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Preclinical and clinical trial data and data from phase IV studies have suggested that levofloxacin causes prolongation of the QT interval. There were cardiovascular problems in 1 in 15 million prescriptions compared with 1-3% of patients taking sparfloxacin, who had QTC prolongation to over 500 ms.

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LEVAQUIN (LEAVE-a-kwin) is an antibiotic proven effective in treating many conditions, such as bronchitis, sinusitis, and urinary tract infections. It is also widely used for the treatment of community-acquired pneumonia. LEVAQUIN should be taken once per day. Your health care professional will determine the number of days you should take it.

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Levofloxacin (Levaquin) is indicated for the treatment of uncomplicated skin infections caused by S. aureus and S. pyogenes. Two large clinical trials in Japan demonstrated levofloxacin’s effects against various skin pathogens, the majority of which were methicillin-sensitive S. aureus or coagulase-negative staphylococci.