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Clarithromycin 500 mg

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Buy Clarithromycin Online

Clarithromycin is authorised in the world under the following brand names: Biaxin, Biaxin XL, Klacid, Klaricid, Macladin, Naxy, Veclam, Zeclar.

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Generic Name: Clarithromycin

Clarithromycin 500mg, powder for concentrate for solution for infusion

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What Clarithromycin Is And What It Is Used For

Read indications for use if you want to order Clarithromycin online

Clarithromycin is an antibiotic that belongs to a group of medicines called macrolides. Antibiotics stop the growth of bacteria which cause infections. Clarithromycin is used whenever an intravenous (injection into the vein) antibiotic is required to treat severe infections or, alternatively, if a patient cannot swallow Clarithromycin tablets.

It is used to treat infections caused by bacteria such as:

  • Chest infections like acute bronchitis and pneumonia.
  • Throat and sinus infections.
  • Skin and tissue infections.

Clarithromycin is not suitable for use in children under 12 years of age.

Before You Are Given Clarithromycin

Before buy Clarithromycin online, read information about the drug

You should not be given Clarithromycin:

  • If you (or your child) are allergic (hypersensitive) to clarithromycin, other macrolides (similar antibiotics such as erythromycin, azithromycin), or any of the other ingredients in this medicine (see list of ingredients in Section 6). An allergic reaction may include rash, itching, difficulty breathing or swelling of the face, lips, throat or tongue.
  • If you are taking ergotamine – like drugs or dihydroergotamine (used to treat migraine and low blood pressure).
  • If you are taking cisapride (used to treat stomach disorders).
  • If you are taking pimozide (used to treat mental illness).
  • If you are taking terfenadine or astemizole (used to treat hay fever or allergy).

If any of the above applies to you, consult your doctor for advice on alternative medicines.

Take special care with Clarithromycin:

  • have any liver or kidney problems.
  • are pregnant or breast feeding.

If any of these apply to you, consult your doctor before being given Clarithromycin.

If you develop severe or prolonged diarrhoea during or after receiving this medicine, consult your doctor immediately (see section 'Possible side effects')

Taking other medicines:

Please tell your doctor or nurse if you are taking or have recently taken any other medicines, including medicines obtained without prescription. Especially if you are taking any of the medicines listed below:

  • Digoxin, quinidine or disopyramide (used to treat heart conditions).
  • Warfarin or other drugs (used to thin the blood).
  • Carbamazepine, valproate or phenytoin (used to treat epilepsy).
  • Theophylline (used to treat breathing difficulties such as asthma).
  • Triazolam (used to induce sleep).
  • Alprazolam (used to treat moderate to severe anxiety).
  • Midazolam (used in anaesthesia).
  • Cilostazol (used to treat poor circulation).
  • Simvastatin or lovastatin (used to treat high cholesterol).
  • Methylprednisolone (used to treat inflammation).
  • Vinblastine (used for the treatment of cancer).
  • Sildenafil (used to treat impotence).
  • Cyclosporin or Tacrolimus (used to reduce the activity of the patient's immune system).
  • Zidovudine (used to treat viral infections).
  • Rifabutin (used in treatment of some infections).
  • Ritonavir, Efavirenz, Nevirapine, Atazanavir, Saquinavir (used to treat HIV infection).
  • Colchicine (used to treat gout).
  • Pimozide (to treat mental problems).
  • Rifampicin (used to treat tuberculosis (TB)).
  • Fluconazole, Itraconazole (used to treat fungal Infections).
  • Verapamil (used to treat hypertension).
  • Tolterodine (used for treatment of urge Incontinence and/or increased urinary frequency).

Clarithromycin does not interact with oral contraceptives.

Pregnancy and breast-feeding

You should tell your doctor if you are pregnant or breast-feeding and he/she will decide if you may be given Clarithromycin.

Driving and using machines:

Do not drive or use machines, if you suffer from one of the following side effects: dizziness, confusion or disorientation. No studies on the effects on the ability to drive and use machines have been performed.

How Clarithromycin Is Given

When you buy cheap Clarithromycin you must know how to use it

Dosage

Clarithromycin may be given for 2 to 5 days by intravenous infusion.

The total duration of treatment should not exceed more than 14 days.

Adults and adolescents: The recommended dose is 1.0 gram daily of Clarithromycin powder for solution for infusion (appropriately diluted), administered as two separate 500mg doses at 12 hourly intervals.

Children under 12 years should not be given Clarithromycin. Your doctor will prescribe another suitable medicine for your child.

Method and Route of administration

Clarithromycin will be given to you by a doctor or nurse. Clarithromycin is prepared by dissolving the powder in the vial in sterile water. The solution obtained is added to a larger volume of sterile liquid, and this is then infused (like being given a blood transfusion) into one of your veins for at least an hour.

If you receive more Clarithromycin than you should

Your doctor or nurse will know how much infusion to give you. If you think you have been given too much Clarithromycin you should talk to your nurse or doctor.

An overdose with Clarithromycin is likely to cause vomiting and stomach pains.

Possible Side Effects

Read side effects if you want cheap Clarithromycin no prescription

If any of the side effects listed below gets serious, or if you notice any side effects not listed in this leaflet, please contact your doctor immediately.

Like all medicines, Clarithromycin, can cause side effects, although not everybody gets them. The chance of having side effects may also depend on whether you take Clarithromycin alone, or with any other medicines.

Some of the side effects of Clarithromycin can be serious. If you suffer from any of the following symptoms you should contact your doctor straight away:

  • Sudden wheeziness or chest tightness, breathing difficulties, swelling of eyelids, face or lips or collapse (fainting) as these may be symptoms of an acute allergic reaction to your medicine.
  • Severe diarrhoea (this could indicate that you are suffering from a condition called "Pseudomembranous colitis").
  • Blistering of the skin, mouth, eyes and genital organs which could indicate a severe adverse reaction.

The following side effects have been reported:

Common side-effects (affecting 1 to 10 in 100 people)

  • Feeling sick or being sick, indigestion.
  • Inflammation, tenderness or pain at the site of injection.
  • Pain in your stomach.
  • Swelling of the mouth or tongue.
  • Your teeth or tongue may become discoloured or you may notice a bitter or metallic taste in your mouth.
  • Oral thrush.
  • Headaches.
  • Increased blood urea nitrogen.

Uncommon side-effects (affecting 1 to 10 in 1000 people)

  • Reduction in the number of white cells.
  • Problems with your liver such as inflammation or raised liver enzymes.
  • Increase in time for your blood to clot.
  • Pain in your joints or muscles, loss of muscle tissue.
  • Jaundice.
  • Allergic reactions ranging from urticaria to mild skin eruptions and angioedema to anaphylaxis.
  • Abnormal kidney function tests.

Rare side-effects (affecting 1 to 10 in 10,000 people)

  • 'Ringing' in the ears (tinnitus).
  • Uncontrolled shaking of your body (fits or seizures).

Very rare side-effects (affecting less than 1 in 10,000 people)

  • Reduction of platelets in your blood which may cause bruising or your nose or gums to bleed.
  • Changes in heart rhythm.
  • Loss of hearing (which returns after stopping treatment).
  • Inflammation of the eye (mainly occurring in patients who take rifabutin (an antibiotic) at the same time).
  • Inflammation of the pancreas or infection of the intestine (caused by bacteria).
  • Liver failure.
  • Low blood sugar (especially in patients taking medicines to treat diabetes).
  • Numbness, tingling or prickling of the skin.
  • Dizziness or loss of balance.
  • Feeling anxious, seeing things or hearing things, feeling confused or disorientated.
  • Difficulty in sleeping or bad dreams.
  • Depression.
  • Inflammation of the kidneys, kidney failure.
  • Sudden onset of a severe rash or blistering or peeling skin. This may be associated with a high fever and joint pains (Stevens-Johnson syndrome/Toxic epidermal Necrolysis).

How To Store Clarithromycin

Before purchase Clarithromycin, you must read how to store

Keep out of the reach and sight of children. Do not use Clarithromycin, after the expiry date which is stated on the carton and vial of the product.

The expiry date refers to the last day of that month.

Do not store above 30°C. Store in the original container in order to protect from light.

The reconstituted solution can be stored for either 6 hours at room temperature or for 48 hours at 5°C.

Medicines should not be disposed of via wastewater or household waste. Your doctor or nurse will dispose of medicines no longer required. These measures will help to protect the environment.

Further Information

What Clarithromycin contains

The active substance is Clarithromycin. Each vial contains 500mg Clarithromycin (as lactobionate).

Each millilitre of final reconstituted/diluted solution for infusion contains 2mg Clarithromycin (as lactobionate).

The other ingredient is Lactobionic acid.

What Clarithromycin looks like and contents of the pack

Type II clear glass vial with a Ph.Eur. Type I bromobutyl stopper with aluminium flip-off cap. Vials are packed in Units of 1,4 and 6. Not all pack sizes may be marketed. Pack size: 500mg

Marketing Authorization Holder:

Goldshield Pharmaceuticals Ltd,

NLA Tower, 12-16 Addiscombe Road, Croydon, Surrey, CR0 0XT, UK.

Manufacturer:

LABORATORIOS ALCALA FARMA,

S.L., Carretera M-300 Km 29,920, Apartado de correos 3728802 Alcala de Henares (Madrid), Spain.

This medicinal product is authorised in the Member States of the EEA under the following Names:

Ireland ― Clarithromycin 500 mg, powder for Concentrate for solution for infusion.

Poland ― Klarytromycyna Goldshield.

United Kingdom ― Clarithromycin 500 mg, powder for Concentrate for solution for infusion.

The following Information Is Intended for medical or healthcare professionals only:

Recommended Administration:

Clarithromycin 500 mg, powder for concentrate for solution for Infusion should be administered into one of the larger proximal veins as an IV infusion over 60 minutes, using a solution concentration of about 2mg/ml.

Clarithromycin should not be given as a bolus or by intramuscular injection.

Step A. Preparation of the vial solution

Inject 10 ml of water for injections into a vial containing the product. Shake until the vial contents have dissolved. Use only water for injections for the dissolution. Other solvents may result in the formation of a precipitate.

Do not use solutions of inorganic salts or solutions containing preservatives.

Store the solution at a temperature between 2 and 8°C and use within 24 hours.

Step B. Preparation of infusion solution

Make up 10ml of the vial solution prepared in step A (containing 500 mg clarithromycin lactobionate) to 250 ml using one of the following solutions:

  • 0.9% Sodium Chloride
  • 5% Dextrose
  • 5% Dextrose in 0.3% sodium chloride
  • 5% Dextrose in 0.45% sodium chloride
  • 5% Dextrose in Ringer's lactate solution and Ringer's lactate solution.

Compatibility with other IV additives has not been established.

Infusion solution prepared in this way contains 2mg / ml of clarithromycin lactobionate.

Store the solution at a temperature between 2 and 8 °C and use within 24 hours.

IMPORTANT: BOTH DILUENT STEPS (A and B) SHOULD BE COMPLETED BEFORE USE.

Dosage:

Clarithromycin may be given for 2 to 5 days by intravenous infusion. The total duration of treatment should not exceed more than 14 days. Adults and adolescents: The recommended dose is 1.0 gram daily of Clarithromycin powder for sulution for infusion (appropriately diluted), administered as two separate 500 mg doses at 12 hourly intervals.

Children under 12 years should not be given Clarithromycin.

Renal Impairment

Patients with severe renal impairment, with creatinine clearance less than 30ml/min, the dosage of clarithromycin should be reduced to one half of the normal recommended dose.

Shelf life

Unopened vials: 4 years

After reconstitution in 10 ml water for injections: Chemical and physical in-use stability has been demonstrated for 24 hours at 25°C and for 24 hours at 5°C. From a microbiological point of view, the product should be diluted immediately. If not diluted immediately in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C.

After dilution to 250 ml in an appropriate diluent: Chemical and physical in-use stability has been demonstrated for 6 hours at 25°C and for 24 hours at 5°C.

From a microbiological point of view, the solution for infusion should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C to 8°C.

Storage

Do not store above 30° C. Store in the original container in order to protect from light. See carton and vial for expiry date. The products should not be used after this date.

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