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Cefuroxime is authorised in the world under the following brand names: Ancef, Biofuroksym, Cedax, Cefizox, Cefobid, Cefotan, Ceftin, Cefurax, Cefuril, Cefzil, Cepazine, Cephuroxime, Duricef, Elobact, Kefurox, Kefzol, Kerurox, Mandol, Maxipime, Mefoxin, Monocid, Oraxim, Rocephin, Sharox, Velosef, Zinacef, Zinat, Zinnat.

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Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

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The manufacturer of Ceftin® (cefuroxime axetil) oral suspension states that safety and efficacy of the suspension have been established only for the treatment of pharyngitis and tonsillitis, acute otitis media, and impetigo caused by susceptible bacteria. Cefuroxime sodium is used parenterally in the treatment of lower respiratory tract infections (including pneumonia), serious skin and skin structure infections, genitourinary tract infections, bone and joint infections, septicemia, and meningitis caused by susceptible organisms.

Community-Acquired Pneumonia: Current Therapies

Many highly effective agents are available for the treatment of bacterial community-acquired pneumonia (community-acquired pneumonia) and other community-acquire respiratory tract infections (RTIs). Currently marketed antibiotics for community-acquired pneumonia demonstrate similar efficacy rates in clinical trials, and these agents have generally achieved clinical symptom resolution in 85-95% of trial participants.

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Cefuroxime axetil (GSK’s Ceftin/Zinnat/Oracef) is a second-generation cephalosporin consisting of an esterified pro-drug of cefuroxime created for oral formulation; the active antibiotic metabolite cefuroxime is released after cefuroxime axetil absorption from the gastrointestinal tract.

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Cefuroxime axetil is indicated for a number of bacterial infections including respiratory tract infections caused by β-lactamase-negative strains of S. pneumoniae, H. influenzae, M. catarrhalis, and Haemophilusparainfluenzae.

Penicillins

The penicillins comprise several subgroups of agents with a wide range of bacterial coverage and efficacy. Each penicillin molecule contains a basic β-lactam structure fused to a five-membered ring. Because of their broad spectrum of activity and availability in oral form, the penicillins are commonly used in the treatment of acute exacerbations of chronic bronchitis and have become the drugs of choice in treating many common infections. The penicillins are further divided into the following groups: natural penicillins, aminopenicillins, and the extended-spectrum penicillins.

Acute Exacerbations of Chronic Bronchitis: Current therapies

TABLE: Pharmacological Management of Underlying Disease During an Acute Exacerbation of Chronic Bronchitis summarizes the general pharmacological agents and classes used to manage acute exacerbations of chronic bronchitis. The primary therapies used in acute exacerbations of chronic bronchitis treat the causative infection (antibiotics), relieve symptoms (bronchodilators), and treat the underlying inflammation (corticosteroids). TABLE: Current Therapies Used for Acute Exacerbations of Chronic Bronchitis summarizes the leading antibiotic therapies used to treat the infection.

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Zinacef 1.5 g, 750 mg or 250 mg (called ‘Zinacef in this leaflet) is a cephalosporin antibiotic for intravenous (IV) injection or infusion or intramuscular (IM) infusion. The intravenous injection or infusion is made into a vein and intramuscular infusion is made into a muscle. Zinacef contains a medicine called cefuroxime (present as cefuroxime sodium).

Dosage forms of Cefuroxime:
Apo-Cefuroxime 250 mg Tablet Ratio-Cefuroxime 250 mg Tablet Velosef 250 mg capsule Ceftin 250 mg Tablet
Velosef 500 mg capsule Apo-Cefuroxime 500 mg Tablet Ratio-Cefuroxime 500 mg Tablet Cefuroxime axetil 250 mg tablet
Ceftin 500 mg Tablet Cefzil 250 mg tablet Duricef 1 gm tablet Cefuroxime axetil 500 mg tablet
Cefzil 500 mg tablet Ceftin 250 mg tablet Cefuroxime sod 1.5 gm vial Zinacef 1.5 gm vial
Zinacef 1.5 gm add-vant vial Cedax 400 mg capsule Cefuroxime 1.5 g/50 ml bag Ceftin 500 mg tablet
Maxipime 1 gram vial Duricef 250 mg/5ml Suspension 50ml Bottle Maxipime 1 gm piggyback vial Velosef 250 mg/5ml Suspension 100ml Bottle
Maxipime 2 gram vial Duricef 500 mg/5ml Suspension 75ml Bottle Cefzil 125 mg/5ml Suspension 100ml Bottle Duricef 500 mg/5ml Suspension 100ml Bottle
Rocephin 1 gm vial Rocephin 1 gm Solution Vial Zinacef 7.5 gm vial Cefzil 250 mg/5ml Suspension 100ml Bottle
Rocephin 2 gm vial Cefuroxime Axetil 250 mg/5ml Suspension 100ml Bottle Ceftin 20 500 mg tablet Bottle Rocephin 10 gm vial
Zinacef-water 1.5 gm/50 ml      

Synonyms of Cefuroxime:

Cefuroxim, Cefuroxime [USAN:BAN:INN], Cefuroximo [INN-Spanish], Cefuroximum [INN-Latin]

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Therapeutic classes of Cefuroxime:

Anti-Bacterial Agents, Cephalosporins

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