Tags: Lorabid

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

Loracarbef (Lorabid Capsules 200, 400 mg)

Carbacephems are b-lactam antibiotics structurally and pharmacologically related to cephalosporins; however, carbacephems contain a methylene group instead of sulfur in the dihydrothiazine ring of the cephalosporin nucleus, resulting in a tetrahydropyridine ring. This structural modification does not affect microbiologic activity, but substantially improves stability in aqueous solution and in serum, plasma, and other body fluids. Loracarbef is the carba analog of cefaclor, a second generation cephalosporin. SumMon® (see Users Guide).


Loracarbef is an oral carbacephem antibiotic. The carbacephems are closely related to the cephalosporins, but replacement of the sulfur atom in the 7-aminocephalosporanic acid nucleus by a methylene group is said to enhance stability. It is used similarly to cefaclor in the treatment of susceptible infections of the respiratory and urinary tracts and of skin and soft tissue.