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Ketoconazole is authorised in the world under the following brand names: Extina, Fungarest, Fungoral, Ketoderm, Ketoisdin, Ketozole, Nizoral, Nizoral a-D, Nizoral a-D Shampoo, Nizoral Cream, Nizoral Shampoo, Orifungal, Orifungal M, Panfungol, Sebazole.

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Patients undergoing esophagectomy are at increased risk of acute lung injury, perhaps related to increased concentrations of thromboxane in the postpulmonary circulation. In 38 consecutive patients undergoing esophagectomy, perioperative ketoconazole, which inhibits thromboxane synthesis, reduced the incidence of acute lung injury. Headache, dizziness, nervousness, and somnolence have been reported.

Candidiasis Mucocutaneous

A mucocutaneous disorder caused by infection with various species of Candida. Candida is normally present, in very small amounts, in the oral cavity, gastrointestinal tract, and female genital tract. Genetics: Chronic mucocutaneous candidiasis is a heterogeneous clinical syndrome that usually presents in childhood and can have an autosomal recessive, dominant or sporadic mode of inheritance. Sera from HIV-infected patients with thrush have been screened for C. albicans genomic expression.

Blastomycosis

Incidence/Prevalence in USA: Ranges from 0.4-4 cases per 100,000 population per year. Higher prevalence in states bordering the Mississippi and Ohio Rivers. Sporadic cases occurring in other areas.

Antifungal Agents

Fungi are eukaryotes, and they share many of the structural and metabolic characteristics of human cells. As a result, designing agents that affect fungi without harming human cells has proved difficult. One major difference between the two cell types is the primary sterol building block used to form the plasma membrane. The fungal plasma membrane consists of ergosterols; the major sterol component of the human plasma membrane is cholesterol.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

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Ketoconazole is administered orally. To ensure absorption in patients with achlorhydria, it has been recommended that each 200 mg of ketoconazole be dissolved in 4 mL of 0.2N hydrochloric acid solution or taken with 200 mL of 0.1N hydrochloric acid.

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The most frequent adverse reactions to ketoconazole are nausea and/or vomiting which have been reported in 3-10% of patients receiving the drug. Abdominal pain, constipation, flatulence, GI bleeding, and diarrhea have also been reported in 1% or less of patients receiving the drug. Adverse GI effects appear to be dose related, are reported less frequently when ketoconazole is administered with food, and usually subside with continued therapy with the drug. Transient increases in serum AST (SGOT), ALT (SGPT), and alkaline phosphatase concentrations have been reported during ketoconazole therapy.

Dosage forms of Ketoconazole:
Ketoconazole 2% cream Nizoral 2% cream Apo-Ketoconazole 200 mg Tablet Novo-Ketoconazole 200 mg Tablet
Nu-Ketocon 200 mg Tablet Kuric 2% cream Ketoconazole 200 mg tablet Extina 2% foam
Nizoral 200 mg tablet Ketoconazole powder Ketoconazole 2% Cream 15 gm Tube Ketoconazole 2% Shampoo 120ml Bottle
Ketoconazole 2% Cream 30 gm Tube Ketoconazole 2% Cream 60 gm Tube Nizoral 2% Shampoo 120ml Bottle Extina 2% Foam 50 gm Can
Extina 2% Foam 100 gm Can Nizoral a-d 1% shampoo Ketoconazole 2% shampoo Ketoderm 2 % Cream

Synonyms of Ketoconazole:

2%, Ketocanazole, Ketoconazol, Ketoconazol [INN-Spanish], Ketoconazole, Ketoconazole [Usan:Ban:Inn:Jan], Ketoconazolum [INN-Latin]

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Therapeutic classes of Ketoconazole:

Antifungal Agents, Antifungals

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