Zithromax (Azithromycin)

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In 3995 patients who took azithromycin 1.5 g in divided doses over 5 days or who took 1 g as a single dose for urethritis/cervicitis adverse events occurred in 12%. In patients over 65 years the rate was 9.3%, and in children under 14 years of age it was 5.4%.

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Torsade de pointes and cardiorespiratory arrest have been reported in a patient with congenital long QT syndrome who took azithromycin. In a prospective study of 47 previously healthy people, there was a modest statistically insignificant prolongation of the QTC interval without clinical consequences after the end of a course of azithromycin 3 g/day for 5 days. Azithromycin can cause ototoxicity. In one study, 8 (17%) of 46 HIV-positive patients had probable (n = 6) or possible (n = 2) ototoxicity with azithromycin.

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Owing to interference by antacids, azithromycin should be given at least 1 hour before or 2 hours after antacids. Antacids containing aluminium and magnesium reduce peak serum concentrations, but the total extent of azithromycin absorption is not altered. The effects of azithromycin 250 mg/day on the pharmacokinetics of desloratadine 5 mg/day and fexofenadine 60 mg bd have been studied in a parallel-group, third-party-blind, multiple-dose, randomized, placebo-controlled study.

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Zithromax (azithromycin) is one of the group of macrolide antibiotics. It is used to treat a number of infections including: Zithromax Tablets should not be used during pregnancy or breast-feeding unless this has been discussed with your doctor.